Each 50 mL ampoules contains 8.4% (1 mEq/mL), Sodium Ions 50 mmol, Bicarbonate Ions 50 mmol.
Each 10 mL ampoules contains 8.4% (mEq/mL), Sodium Ions 10 mmol, Bicarbonate Ions 10 mmol.
To combat acidosis and sodium loss.
Pharmaco-Therapeutic Group: Solution for Electrolyte Substitution.
For the correction of acidosis. It may be used in the treatment of diabetic coma, eclampsia, etc., preferably diluted with an equal quantity of sterile water for injection. It may be used with caution at full strength in the initial treatment of metabolic acidosis caused by cardiac arrest. It may also be used in the initial treatment of cholera and severe diarrhea, but the addition of potassium becomes necessary if continued treatment is needed.
By intravenous injection, from 10 to 150 mL may be given according to the degree of hyponatremia.
For correction of metabolic acidosis the dose depends on the degree of the disorder of the acid-base status.
According to the blood gas values the amount to be administered is calculated according to the following formula: See equation.
# mL of 1 M (8.4% w/v) sodium bicarbonate solution base deficit x kg BW x 0.3
(The factor 0.3 corresponds to the proportion of the extracellular fluid relation to total body fluid).
Example: If in patient of 70 kg BW the base deficit is 5 mmol/L, then 5 x 70 x 0.3 = 105 mL of 8.4% w/v Sodium Bicarbonate Injection are not to be given.
Correction of metabolic acidosis should not be too rapidly. It is advisable to start administering only half of the calculated dose and adjust further doses according to the actual results of the blood gas analysis.
For urine alkalization the dose is adjusted according to the desired pH of the urine and administration should be accompanied by monitoring of the acid-base balance and the water balance. Care should be taken not to exceed the maximum infusion rate stated as follows.
Maximum Daily Dose: According to the correction requirement.
Flow Rate: Up to 1.5 mmol of sodium bicarbonate/kg BW/h, corresponding to 1.5 mL solution/kg BW/h.
Method of Administration: Intravenous Use.
The solution must be administered via a central vein.
8.4% w/v Sodium Bicarbonate Injection must not be administered to patients with Respiratory and metabolic alkalosis, Hypernatraemia, Hypokalaemia.
Patients are advised to inform their doctor or pharmacist of any adverse effect they experienced in connection with the administration of this drug.
Treatment must be stopped when signs of hyponatraemia begin to appear, such as restlessness, thirst, reduced salivation, swollen tongue, flushing dizziness, tachycardia or respiratory arrest.
Administration of Sodium Bicarbonate Injection may lead to hypernatraemia, and serum hyperosmolarity.
Urine alkalization by sodium bicarbonate accelerates the elimination of acid drug substances e.g acetylsalicylic acid and delays the elimination of the basic drug substances.
Sodium Bicarbonate may interact with gluco and mineralocorticoids, androgens and diuretics increasing the potassium excretion.
Due to their pH, Sodium bicarbonate solutions are incompatible with most medicaments. In particular they must not be administered simultaneously with solutions containing calcium, magnesium phosphate because of the possibility of precipitation.
Store at temperatures not exceeding 30°C.
B05XA02 - sodium bicarbonate ; Belongs to the class of electrolyte solutions used in I.V. solutions.
Phil Pharmawealth/Atlantic Sodium Bicarbonate soln for infusion 8.4%
10 mL x 50 × 1's;50 mL x 50 × 1's
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